Fast Delivery Simeprevir Tmc 435350 CAS No. 923604-59-5

• CAS No.: 923604-59-5
• Formula: C38h47n5o7s2
• EINECS: 689-150-1
• Type: Synthesis Material Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: 923604-59-5
• Colour: White
• Transport Package: Customers′ Requirement
• Origin: China
• Production Capacity: 30000

Product Description

  

 

Product Description

Product Name: Simeprevir

CAS: 923604-59-5

Product Name	Simeprevir
CAS	923604-59-5
MF	C38H47N5O7S2
MW	749.94
Density	1.38
pka	4.47±0.40
Shelf life	2 Years
Molecular formula

Simeprevir does not rely on formation of a covalent intermediate to inhibit the enzyme, but instead gains binding affinity through a large P2  substituent that occupies an extended S2 subsite of HCV protease by induced fit. This pocket is not occupied by inhibitors such as telaprevir and boceprevir. Other key features of simeprevir are truncation of the P3 capping group (the N-methyl amide), use of an acylsulfonamide as an acid isostere, and incorporation of an isopropylthiazole group to give improved permeability. Simeprevir is a potent NS3/4A PI (Ki=0.36 nM), with antiviral activity in the HCV replicon assay (genotype 1b EC50=7.8 nM; genotype 1a EC50=28.4 nM). It is 25-fold less potent against HCV genotype 2, >1000 less potent for HCV genotype 3, but has 3-fold better potency for HCV genotype 4.


 

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