R/D Supply with High Purity Vorinostat CAS No 149647-78-9

• Powder: Yes
• Customized: Non-Customized
• Certification: ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Solid
• Purity: >98%
• Model NO.: 149647-78-9
• Packing: Aluminum Foil Bag
• Storage: Rt
• MOQ: 1kg
• Lead Time: Ready Stock
• Transport Package: Aluminun Foil Bag
• Specification: 1kg/Bottle or 25kg/Drum
• Trademark: NM
• Origin: China
• HS Code: 2932999099
• Production Capacity: 2kg/Month

Product Description

Product Description

 

Product name	Vorinostat
MOQ	1G
CAS NO	149647-78-9
Purity	NLT 98%
Appearance	White powder
Melting point	161-162ºC
Density	1.6740

Vorinostat is the first drug in a new class of anti-cancer agents that inhibit histone deacetylases (HDAC). It was launched as an oral treatment for cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL) who have progressive, persistent, or recurrent disease on or following two systemic therapies. HDACs are enzymes that catalyze the removal of the acetyl modification on lysine residues of proteins, including the core nucleosomal histones. Together with their counterpart histone acetyltransferases (HATs), HDACs regulate the acetylation level of the histones, which plays an important role in the regulation of chromatin plasticity and gene transcription. Hypoacetylation of histones is associated with a condensed chromatin structure resulting in the repression of gene transcription, whereas acetylated histones are associated with a more open chromatin structure and activation of transcription. In some cancer cells, there is an overexpression of HDACs, resulting in hypoacetylation of histones. Inhibitors of HDAC are thought to transcriptionally reactivate dormant tumor-suppressor genes by allowing for the accumulation of acetyl groups on histones and an open chromatin structure. Vorinostat inhibits the enzymatic activity of HDAC1, HDAC2, HDAC3, and HDAC6 at nanomolar concentrations (IC50 <86 nM). In addition, vorinostat inhibits tumor growth in animal models bearing solid tumors, including breast, prostate, lung and gastric cancers, as well as hematologic malignancies such as multiple myeloma and leukemias.

Product Parameters

 

Company Profile

Packaging & Shipping

Packing Method:

For small samples quantity <1 kilograms, inside we use double resealable zip bags and outside with aluminium Foil Bags.

For medium quanity 1-25 kilograms, inside we use double resealable zip bags and outside with aluminium Foil Bags, then packed in cartons or small drums for shipping.

For larger quanity >25 kilograms, inside we use double resealable zip bags and outside with aluminium Foil Bags OR bigger size double seal PET bags for 25kgs in bulk then packed in drums for shipping.

Please contact us for more details if you have any question!

 

Our Advantages

FAQ

Q1: Can I get a sample?
A: We do provide our clients small sample (Sample size from 1-50grams). Free samples can be provided for some products due to the material cost.

Q2: How to start orders or make payments?
A: You can send us your Purchase Order (PO), or just send a simple confirmation by email or by Trade Manager.

Q3: What's your Minimum Ordering Quantity (MOQ)?
A: Products' MOQ depend on their value, please kindly confirm specific items with our online sales.

Q4: Is there a discount?
A: Yes, we offer low prices for larger quantities. There will be different price range on our quotation list so please inform us with quantity you will be after.