| Certification: | RoHS, BRC, ISO, FDA, HACCP |
|---|---|
| Assay Method: | HPLC, UV |
| Application Form: | Lotion, Suppository, Tablet, Capsule |
| Application: | Food, Health Care Products, Medicine |
| State: | Powder |
| Extract Source: | Chinese IVY Leaf Extract |
| Customization: |
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Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
| Product name | Hederagenin |
| CAS number | 465-99-6 |
| Molecular Formula | C30H48O4 |
| Molecular Weight | 472.71 |
| Grade | Research-grade |
| Appearance | White Powder |
| Assay | 98% |
| Place of Origin | Shandong China |
Shandong Natural Micron Pharm Tech Co., LTD and Shandong HRC Chemical Co.,LTD belongs to Natural Micron International Group which founded in 2012. Since its inception, Natural Micron has been specializing in research, development, production and marketing of high-end chemicals(Especially carbohydrate derivatives) and nutrition ingredients. After years of development, Natural Micron has established long-term and stable partnership with dozens of health brands and pharmaceutical companies in the United States, Europe, Australia, New Zealand and other places.
As the R&D Centre and Production base of Natural Micron Group, Natural Micron Pharm Tech and HRC Chemical has been in reform of the evolving continuously for years. Our R&D team not only improves the existing products by applying new technologies to improve the quality and optimize our costs, but we also research and develop new advanced products according to the demands of the market.
In addition, we also provide customization services of various scales from trail production to industrial production. Most of our R&D team members are Ph.D. and M.A. from overseas and China Pharmaceutical University (The best pharmaceutical university in China). They have rich experience in chemical research and develop. We can design the production processes, small to medium scale laboratory trials and cost accounting for industrial production due to our customers' requirements. Our R&D center is also equipped with a preparation workshop for finished products' stability testing and simple evaluation of products' effects.
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