| Product Name |
Dolutegravir Sodium |
| CAS |
1051375-19-9 |
| MF |
C20H20F2N3NaO5 |
MW
|
443.38 |
EINECS
|
812-620-6 |
Dolutegravir sodium (Tivicay), developed and marketed by GlaxoSmithKline, was approved by the FDA in August 2013 as a novel integrase inhibitor for the treatment of HIV infection. Dolutegravir was fast-tracked by the FDA in February 2012, and joins an important class of drugs known as Integrase Strand Transfer inhibitors (INSTi's). INSTi's are characterized by their two-metal-chelating scaffolds, which are known to chelate Mg2+ cofactors in the enzyme active site, l interrupting function of HIV-1 integrase, which is essential for replication of viral DNA into host chromatin.Other drugs in this class, raltegravir and elvitegravir, are known to require either high dosages or PK boosting agents, respectively, with raltegravir also exhibiting substantial loss of potency in several major HIV-1 integrase mutation pathways. Dolutegravir was pursued with the goal of developing a novel INSTi with a once-daily, low-dosage treatment with improved resistance profile and without the need for the use of a PK boosting agent. Dolutegravir sodium has been approved for treating a broad population of HIV-infected patients, including adults undergoing their first treatment as well as those who have been treated with other integrase transfer strand inhibiting agents.
Q:How to order a sample for quality testing purpose before your commercial order?
A: We do provide our clients small sample for quality testing purpose (Sample size form 1-50 grams). Free samples can be provided for some products due to the material cost, Our clients only need to pay the international shipping cost or provide us your Fedex/DHL account number so we can arrange the shipments. so please contact us in details by email.
Q: How to start orders or make payments?
A: You can send us your Purchase order(PO), or just send a simple confirmation by email, after communication then we will send you Proforma Invoice with our bank details for final confirmation, then you can make payment accordingly.
Q: What's our Minimun Ordering Quantity (MOQ)?
A: For the high value products, our MOQ starts from 1 gram and other products generally starts from 1 kilogram. For other low value products, MOQ can be started from 10kgs to 100kgs.
Q: Is there a discount?
A: Yes, we offer lower prices for larger quantities. There will be difference prices range on our quotation list so please inform us what quantity you will be after.
Q: How do we guarantee our products quality?
A: First of all, our quality control system will reduce our quality problem to near zero.We can always provide our certificate of analysis according to every batch of our products.We can also provide third party analysis testing due to our clients' requirement.
If there is any quality issue caused by us, we will send you free goods for replacement or refund your loss.
Q: How to contact us ?
A: You can contact us thought inquiries to message box of any of our products displayed or sent us emails to our company email address or simply call us at anytime!
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